We study the computational content of various theorems with reverse mathematical strength around Arithmetical Transfinite Recursion (ATR_0) from the point of view of computability-theoretic reducibilities, in particular Weihrauch reducibility. Our main result states that it is equally hard to construct an embedding between two given well-orderings, as it is to construct a Turing jump hierarchy on a given well-ordering. This answers a question of Marcone. We obtain a similar result for Fraïssé's conjecture restricted to well-orderings.

In this work we investigate the Weihrauch degree of the problem Decreasing Sequence of finding an infinite descending sequence through a given ill-founded linear order, which is shared by the problem Bad Sequence of finding a bad sequence through a given non-well quasi-order. We show that $\mathsf {DS}$, despite being hard to solve, is rather weak in terms of uniform computational strength. To make the latter precise, we introduce the notion of the deterministic part of a Weihrauch degree. We then (...) generalize $\mathsf {DS}$ and $\mathsf {BS}$ by considering $\boldsymbol {\Gamma }$ -presented orders, where $\boldsymbol {\Gamma }$ is a Borel pointclass or $\boldsymbol {\Delta }^1_1$, $\boldsymbol {\Sigma }^1_1$, $\boldsymbol {\Pi }^1_1$. We study the obtained $\mathsf {DS}$ -hierarchy and $\mathsf {BS}$ -hierarchy of problems in comparison with the Baire hierarchy and show that they do not collapse at any finite level. (shrink)

Halin in 1965 proved that if a graph has [Formula: see text] many pairwise disjoint rays for each [Formula: see text] then it has infinitely many pairwise disjoint rays. We analyze the complexity of this and other similar results in terms of computable and proof theoretic complexity. The statement of Halin’s theorem and the construction proving it seem very much like standard versions of compactness arguments such as König’s Lemma. Those results, while not computable, are relatively simple. They only use (...) arithmetic procedures or, equivalently, finitely many iterations of the Turing jump. We show that several Halin-type theorems are much more complicated. They are among the theorems of hyperarithmetic analysis. Such theorems imply the ability to iterate the Turing jump along any computable well ordering. Several important logical principles in this class have been extensively studied beginning with work of Kreisel, H. Friedman, Steel and others in the 1960s and 1970s. Until now, only one purely mathematical example was known. Our work provides many more and so answers Question 30 of Montalbán’s Open Questions in Reverse Mathematics in 2011. Some of these theorems including ones in Halin in 1965 are also shown to have unusual proof theoretic strength as well. (shrink)

Theorems of hyperarithmetic analysis occupy an unusual neighborhood in the realms of reverse mathematics and recursion-theoretic complexity. They lie above all the fixed iterations of the Turing jump but below ATR $_{0}$. There is a long history of proof-theoretic principles which are THAs. Until the papers reported on in this communication, there was only one mathematical example. Barnes, Goh, and Shore [1] analyze an array of ubiquity theorems in graph theory descended from Halin’s [9] work on rays in graphs. They (...) seem to be typical applications of ACA $_{0}$ but are actually THAs. These results answer Question 30 of Montalbán’s Open Questions in Reverse Mathematics [19] and supply several other natural principles of different and unusual levels of complexity.This work led in [25] to a new neighborhood of the reverse mathematical zoo: almost theorems of hyperarithmetic analysis. When combined with ACA $_{0}$ they are THAs but on their own are very weak. Denizens both mathematical and logical are provided. Generalizations of several conservativity classes are defined and these ATHAs as well as many other principles are shown to be conservative over RCA $_{0}$ in all these senses and weak in other recursion-theoretic ways as well. These results answer a question raised by Hirschfeldt and reported in [19] by providing a long list of pairs of principles one of which is very weak over RCA $_{0}$ but over ACA $_{0}$ is equivalent to the other which may be strong or very strong going up a standard hierarchy and at the end being stronger than full second-order arithmetic. (shrink)

Recall that B is PA relative to A if B computes a member of every nonempty $\Pi ^0_1(A)$ class. This two-place relation is invariant under Turing equivalence and so can be thought of as a binary relation on Turing degrees. Miller and Soskova [23] introduced the notion of a $\Pi ^0_1$ class relative to an enumeration oracle A, which they called a $\Pi ^0_1{\left \langle {A}\right \rangle }$ class. We study the induced extension of the relation B is PA relative (...) to A to enumeration oracles and hence enumeration degrees. We isolate several classes of enumeration degrees based on their behavior with respect to this relation: the PA bounded degrees, the degrees that have a universal class, the low for PA degrees, and the ${\left \langle {\text {self}\kern1pt}\right \rangle }$ -PA degrees. We study the relationship between these classes and other known classes of enumeration degrees. We also investigate a group of classes of enumeration degrees that were introduced by Kalimullin and Puzarenko [14] based on properties that are commonly studied in descriptive set theory. As part of this investigation, we give characterizations of three of their classes in terms of a special sub-collection of relativized $\Pi ^0_1$ classes—the separating classes. These three can then be seen to be direct analogues of three of our classes. We completely determine the relative position of all classes in question. (shrink)

In their logical analysis of theorems about disjoint rays in graphs, Barnes, Shore, and the author (hereafter BGS) introduced a weak choice scheme in second-order arithmetic, called the $\Sigma ^1_1$ axiom of finite choice (hereafter finite choice). This is a special case of the $\Sigma ^1_1$ axiom of choice ( $\Sigma ^1_1\text {-}\mathsf {AC}_0$ ) introduced by Kreisel. BGS showed that $\Sigma ^1_1\text {-}\mathsf {AC}_0$ suffices for proving many of the aforementioned theorems in graph theory. While it is not known (...) if these implications reverse, BGS also showed that those theorems imply finite choice (in some cases, with additional induction assumptions). This motivated us to study the proof-theoretic strength of finite choice. Using a variant of Steel forcing with tagged trees, we show that finite choice is not provable from the $\Delta ^1_1$ -comprehension scheme (even over $\omega $ -models). We also show that finite choice is a consequence of the arithmetic Bolzano–Weierstrass theorem (introduced by Friedman and studied by Conidis), assuming $\Sigma ^1_1$ -induction. Our results were used by BGS to show that several theorems in graph theory cannot be proved using $\Delta ^1_1$ -comprehension. Our results also strengthen results of Conidis. (shrink)

Background Supporting physicians in Intensive Care Units s as they face dying patients at unprecedented levels due to the COVID-19 pandemic is critical. Amidst a dearth of such data and guided by evidence that nurses in ICUs experience personal, professional and existential issues in similar conditions, a systematic scoping review is proposed to evaluate prevailing accounts of physicians facing dying patients in ICUs through the lens of Personhood. Such data would enhance understanding and guide the provision of better support for (...) ICU physicians. Methods An SSR adopts the Systematic Evidenced Based Approach to map prevailing accounts of caring for dying patients in ICUs. To enhance the transparency and reproducibility of this process, concurrent and independent use of tabulated summaries, thematic analysis and directed content analysis is adopted. Results Eight thousand three hundred fifty-eight abstracts were reviewed from four databases, 474 full-text articles were evaluated, 58 articles were included, and the Split Approach revealed six categories/themes centered around the Innate, Individual, Relational and Societal Rings of Personhood, conflicts in providing end of life care and coping mechanisms employed. Conclusion This SSR suggests that caring for dying patients in ICU impacts how physicians view their personhood. To resolve conflicts within individual concepts of personhood, physicians use prioritization, reframing and rely on accessible, personalized support from colleagues to steer coping strategies. An adapted form of the Ring Theory of Personhood is proposed to direct timely personalized, appropriate and holistic support. (shrink)

The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

" L'argent est l'envers de toutes les images que le cinéma montre et monte à l'endroit " écrit Gilles Deleuze dans le deuxième volet de Cinéma. Le capital est toujours derrière le cinéma. Le Capital hante Cinéma du début à la fin. C'est donc une lecture marxiste du diptyque composé de L'Image-mouvement et L'Image-temps que propose Jun Fujita dans Ciné-capital. Comment fonctionne le mode de production ciné-capitaliste? Comment celui-ci fait-il produire de la plus-value aux images? Pourquoi et comment s'approprie-t-il le (...) travail même du spectateur? En quel sens peut-on soutenir qu'Eisenstein et Hitchcock ont anticipé l'arrivée de la New Economy des années 1990 (dématérialisation du travail et financiarisation de l'économie)? Quand et comment les images s'insurgent-elles contre l'exploitation ciné-capitaliste? Comment se mettent-elles à valoir pour elles-mêmes? Pourquoi le cinéma politique, depuis Straub et Huillet, a-t-il cessé de privilégier le tournage au bord de la mer? Qu'est-ce qui permet à Deleuze d'affirmer qu'Ozu est un cinéaste de gauche? Telles sont quelques-unes des questions abordées dans Ciné-capital. (shrink)

Di ka mi shi ou zhou jin dai li xing zhu yi zhe xue de chuang shi ren. ben shu li tu dui di ka mi di yi zhe xue de si xiang zuo yi quan mian yan jiu, dui ta de fang fa lun " wo si gu wo zai " wu fu guan nian lun, xin shen guan xi deng zhu yao li lun jin xing le xi tong yan jiu.

Ben shu xi tong jie shi le zhi jue lun si xiang zai zhong guo xian dai zhe xue fa zhan yan bian de gui ji, Fen xi le liang shu ming, Xiong shi li, Feng you lan, He lin, Mou zong san, Fang dong mei, Tang jun yi deng ren yun yong zhi jue fang fa lai jian gou ge zi zhe xue si xiang ti xi zhi de yu shi, Ji you zhuan ti yan jiu de shen du, (...) You jian gu le shi de guang du, Xian ming gou le chu zhi jue lun zai zhong guo xian dai zhe xue yan jiu zhong de du te lun kuo. (shrink)

Le concept de caractère se distingue de ceux d’individu ou d’essence en ce qu’il ne fonctionne pas à partir du principe d’individuation permettant de déterminer la limite et l’extension d’un objet en tant qu’unité insécable ou catégorie scientifique. Le caractère d’un objet est sa propriété la plus représentative définie par la méthode pratique et les projets quotidiens. Le critère en est le mouvement de la totalité de l’histoire en relation avec l’activité des hommes en société. Il développe une théorie alternative (...) au modèle de la logique formelle. (shrink)

La « diversité culturelle » et le « dialogue interculturel » prônés par l'Unesco à la suite des événements du 11 septembre 2001 demandent à être soutenus, mais à condition de développer des synergies qui soient véritablement interculturelles, à l'instar de celles qui se sont créés en Occident à plusieurs moments de son histoire. Il ne faut pas oublier que ce phénomène s'est également produit ailleurs: c'est notamment le cas de la Chine, qui s'est ouverte au monde extérieur à plusieurs (...) reprises, tout d'abord à l'Inde, puis, principalement à partir du XIXe siècle, à l'Occident. Toutes les aires culturelles doivent être prises en compte dans le cadre de la mondialisation, ce qui ne peut véritablement se faire qu'à travers la traduction."Cultural diversity" and "intercultural dialogue" advocated by UNESCO following the events of September 11, 2001 need to be supported, but provided synergies that are truly intercultural, like those are created in the West several times in its history. It must not be forgotten that this phenomenon also occurred elsewhere: the case of China, which opened to the outside world several times, first in India and then, mainly from the nineteenth century   e in the West. All cultural areas must be taken into account in the context of globalization, which can really only be done through translation. (shrink)

In this paper, we consider a pseudo-parabolic equation, which was studied extensively in recent years. We generalize and extend the existing results in the following three aspects. First, we consider the vacuum isolating phenomenon with the initial energy \\) satisfying \\le 0\) and \ (...) asymptotic behaviors of the solutions and the energy functional. Generally speaking, we establish the exponential decay of the solutions and energy functional when the solutions exist globally, and the concrete decay rate is given. As for the blow-up solutions, we prove that the solutions grow exponentially and obtain the behavior of energy functional as the time t tends to the maximal existence time. We get further two necessary and sufficient conditions for the solutions existing globally and blowing up in finite time, respectively, under the assumption that \shrink)

Kichul Kim, né en 1969 à Séoul, a ceci de remarquable qu’il prétend — et réussit — à sculpter le son. En effet, il a une formation de sculpteur. Mais il se fascine très tôt pour le son, pour des raisons spirituelles. L’énigme du bodhisattva Gwan-eum qui, selon l’étymologie de son nom, « voit ou fait voir les sons », l’intrigue. Une intuition lui révèle — pense-t-il — de quoi il s’agit. Il va s’efforcer de le faire voir à son (...) tour. Le son fait voir, visualiser, évoquer, et on peut donc, en ce sens, voir le son. Ses installations sonores sont en général réalisées dans des formes minimales et simplifiées. Ces formes pures ne correspondent qu’au son qu’il veut diffuser. C’est le son qu’émettent des haut-parleurs, un son qu’il a enregistré et qui parle. En effet, le son, tout invisible et intangible qu’il est, par l’espace qu’il recrée et modèle, est tridimensionnel, et sculptable. Le spectateur ne peut certes pas voir ce travail sonore par ses yeux de chair, pas plus qu’il ne peut le toucher de sa main, mais son œil de l’imagination, son imagination visuelle, le construit, et en ce sens il le perçoit bien : à partir du son se crée une image, une image dont l’intensité frôle l’illusion. On a là un véritable environnement créé par le son. Inspiré par l’Extrême-Orient ancien, son art et sa pensée, Kichul Kim puise dans ses sites historiques, religieux souvent, et dans la nature, son inspiration et ses enregistrements. L’environnement particulier d’origine est rendu présent par son son, si puissamment que l’auditeur devient spectateur, recréant activement la scène originelle : spect-acteur. Plongé si profondément en lui-même, il est graduellement conduit aux portes d’une sorte de méditation, ici et ailleurs à la fois, comme hors du temps. Kichul Kim, born in 1969 in Seoul, is remarkable in that he claims—and succeeds—to carve the sound. He trained as a sculptor but was fascinated very early with the sound, for spiritual reasons. The enigma of the Bodhisattva Gwan-eum which, according to the etymology of its name, “sees or makes one see sounds”, intrigued him. He understood intuititvely what it means and tried to examplify it himself. The sound makes you see, visualize, evoke, and you can, in this sense, see the sound. His sound installations are generally performed in minimal and simplified forms. These pure forms correspond only to the sound he wants to produce. This is the sound emitted through loudspeakers, a sound that he recorded and that speaks. Indeed, the sound, as invisible and intangible as it is, thanks to the space it recreates and models, becomes three-dimensional, and “sculptable”. The spectator certainly cannot see this sonic work through his/her eyes of flesh, any more than he/she can touch it with his/her hand. But his/her eye of the imagination, the visual imagination, builds it, and in this sense he/she perceives it well: from the sound is created an image whose intensity borders on illusion. This is a real environment created by sound. Inspired by the ancient Far East, its art and thought, Kichul Kim draws from historical sites, often religious, and from nature, for his inspiration, and recordings. The particular environment of which the sounds originates is made present by the sound, so powerfully that the listener becomes a spectator, actively recreating the original scene: spect-actor. So deeply immersed in himself, he is gradually led to the gates of a kind of meditation, here and elsewhere at once, as if out of time. (shrink)

Cette publication bienvenue fait lumière sur la littérature tardo-antique des prolégomènes : introductions à la philosophie, aux corpus d’Aristote (en part. l’Organon) et Platon, ou aux œuvres de ces corpus. Le livre est ainsi composé : présentation ; cinq articles arrangés chronologiquement ; abréviations ; bibliographie (p. 185-205). On regrettera l’absence d’index. Le titre de l’ouvrage sonne curieusement, comme s’il était une introduction à la philosophie néoplatonicienne plutôt qu’une ét...

Auditory perception is traditionally conceived as the perception of sounds — a friend’s voice, a clap of thunder, a minor chord. However, daily life also seems to present us with experiences characterized by the absence of sound — a moment of silence, a gap between thunderclaps, the hush after a musical performance. In these cases, do we positively hear silence? Or do we just fail to hear, and merely judge or infer that it is silent? This longstanding question remains controversial (...) in both the philosophy and science of perception, with prominent theories holding that sounds are the only objects of auditory experience and thus that our encounter with silence is cognitive, not perceptual. However, this debate has largely remained theoretical, without a key empirical test. Here, we introduce a novel empirical approach, presenting experimental evidence that silence can be genuinely perceived (not just cognitively inferred). We ask whether silences can ‘substitute’ for sounds in event-based auditory illusions — empirical signatures of auditory event representation in which auditory events distort perceived duration. Seven experiments introduce three new ‘silence illusions’ — the one-silence-is-more illusion, silence-based warping, and the oddball-silence illusion — each adapted from a prominent perceptual illusion previously thought to arise only from sounds. Subjects were immersed in ambient noise interrupted by silences structurally identical to the sounds in the original illusions. In all cases, silences elicited temporal distortions perfectly analogous to the illusions produced by sounds. Our results suggest that silence is truly heard, not merely inferred, introducing a general approach for studying absence perception. (shrink)

Tosaka Jun (1900-1945) was one of modern Japan's most unique and important critics of capitalism, the emperor system, imperialism, and everyday life in wartime Japan. This collection of translations contains some of Tosaka's most important essays and original articles on Tosaka.

沈黙を強いられた時代にひそかに続けられた抵抗。総動員体制と戦争のさなか名を秘して書き綴られた戦闘的唯物論者の論文を発掘!

教育とは「文化的記憶」との接触により生じる学びを意図的に促す試みでもある。教育哲学や文学から記憶/想起について様々に論じる。 記憶(憶えとどめておく能力とそのための仕組み)と想起(特定の内容を再び呼び起こす動的な過程)は、教育および人間形成とどうかかわるのか。この問いに対し、教育哲学を足場として多様な視角から検討する。人間形 成に関する学問と記憶の関係、書くことや記憶継承をめぐる問題について論じつつ、〈記憶の教育学〉モデルを構想する。.

Each Olympic Games will offer fresh research material in the fields of social and sports philosophy. This article uses Beijing 2022 Winter Olympic Games (B2022WOG) as an illustration to discuss the difficulty in viewing sports as contributors to social progress. We have examined the phenomena of fusing classical Chinese philosophy with social sports philosophy, as exemplified by the current Olympic movement. The key finding is that the fusion of Eastern and Western cultures and civilizations is responsible for sports revival as (...) a social force in the modern era. As a result, new social cognition emerges. The leadership of the nations hosting the Olympic Games gains knowledge and the chance to showcase their own political, economic, and solid philosophical underpinnings. The B2022WOG, taking place in a completely new societal environment (COVID-19 pandemic, world power realignment), is used as a case study for analysis. Using this example, the artіcle shows the social significance of the Olympic Games and emphasizes that the social value of sports and the Olympic movement is reflected in the "spirit of fair competition" and the "spirit of peace", "human intelligence". This is a relatively new direction in the development of researcհ in the field of physical education and social philosophy, and the special contrіbutіon of this study is to study one of the promising trends in the development of sports, that is, the modern Olympic movement, integrated with the national culture of different countries, B2022WOG were utilized as a case study for research since they are taking place in a totally new social context (COVID-19 pandemic, realignment of global power). By using this illustration, the article highlights the social significance of the Olympic Games and stresses how the "spirit of fair competition", "spirit of peace" and "human intelligence" are reflections of the social worth of sports and the Olympic movement. This is a relatively new area of study in the fields of physical education and social philosophy, and the focus of this research is to examine one of the most encouraging developments in the field of sports — the modern Olympic movement — as it interacts with various national cultures. (shrink)

Alvin Plantinga has famously responded to the logical problem of evil by appealing to the intrinsic value of significant free will. A problem, however, arises because traditional theists believe that both God and the redeemed who go to heaven cannot do wrong acts. This entails that both God and the redeemed in heaven lack significant freedom. If significant freedom is indeed valuable, then God and the redeemed in heaven would lack something intrinsically valuable. However, if significant freedom is not intrinsically (...) valuable, then Plantinga’s reply to the logical problem of evil fails. In this paper, we assess three contemporary solutions to the dilemma above. The first is the love solution, which proposes that significant freedom is necessary for agents to love, and loving others is intrinsically good. The second is the soul-making solution, which argues that significant freedom is necessary for self-developing one’s moral character, and having a self-developed moral character is intrinsically good. The third is the derivative free will solution, which argues that significant freedom is necessary for derivative free will in heaven, and derivative free will is intrinsically good. We raise problems against all three solutions and instead defend a fourth solution – the ultimate responsibility solution. That is, significant freedom is instrumentally valuable as it gives agents ultimate responsibility with regards to morally significant acts. Finally, we defend the ultimate responsibility solution against two major objections. (shrink)

A translation of a Japanese text written by philosopher Tosaka Jun in 1935, at the moment the country had begun to embark upon a course of fascist authoritarianism that led to war and total destruction. Titled The Japan Ideology, the text purposely recalls its derivation and kinship with Marx and Engels's The German Ideology and expands on the role played by philosophic idealism in preparing the population for both the new politics of fascism and the demands of the eventual war (...) it brought. In its penetrating analysis of the relationship between philosophy and the formation of ideology in a politically critical and crucial historical time, this foundational work in the Japanese Marxist tradition remains accessible and timely, speaking forcibly to conditions that continue to persist in Japan and everywhere in today's world. (shrink)

Over the past decade philosophers of biology have discussed whether evolutionary theory is a causal theory or a phenomenological study of evolution based solely on the statistical features of a population. This article reviews this controversy from three aspects, respectively concerning the assumptions, applications, and explanations of evolutionary theory, with a view to arriving at a definite conclusion in each contention. In so doing I also argue that an implicit methodological assumption shared by both sides of the debate, namely the (...) overconfidence in conceptual analysis as a tool to understand the scientific theory, is the real culprit that has both generated the problem and precluded its solution for such a long time. (shrink)

The causal nature of evolution is one of the central topics in the philosophy of biology. The issue concerns whether equations used in evolutionary genetics point to some causal processes or purely phenomenological patterns. To address this question the present article builds well-defined causal models that underlie standard equations in evolutionary genetics. These models are based on minimal and biologically plausible hypotheses about selection and reproduction, and generate statistics to predict evolutionary changes. The causal reconstruction of the evolutionary principles shows (...) adaptive evolution as a genuine causal process, where fitness and selection are both causes of evolution. 1 Introduction2 The Philosophical Puzzle3 Causal Models4 Causal Foundations of Evolutionary Genetics4.1 Univariate quantitative genetics model4.1.1 The causal graph4.1.2 Structural equations4.1.3 Deriving evolutionary transition functions4.2 One-locus population genetics model5 Evolution as a Causal Process5.1 Selection as a causal process5.2 Causes of evolutionary change6 Conclusion. (shrink)

Background Participants' understanding of clinical trials is important in informed consent. However, little is known about what information participants really want to know. Aims To demonstrate the existence of a discrepancy between participants' understanding and their desire to know. Methods The participants in clinical trials at Seoul National University Hospital were surveyed. The survey consisted of 11 statements based on the essential elements of informed consent. The participants gave two responses to each statement on a five-point Likert scale to rate (...) their subjective understanding and desire to know, respectively. Information discrepancy was defined as the difference between these two ratings: if understanding exceeded desire to know for a particular item, it was defined as ‘over-informed’; if desire to know exceeded understanding for a particular item, it was defined as ‘under-informed’. Results Participants reported good understanding of ‘voluntariness’, ‘duration’, ‘study involves research’ and poor understanding of ‘confidentiality’, ‘compensation’, ‘benefits’, ‘procedures’ and ‘risks or discomforts’. For ‘risks or discomforts’, ‘who to contact’, ‘voluntariness’, ‘duration’ and ‘procedures’, participants reported high desire to know compared with ‘confidentiality’, ‘purpose’, ‘study involves research’ and ‘benefits’. The elements ‘study involves research’, ‘voluntariness’, ‘duration’, ‘purpose’ and ‘who to contact’ were over-informed, while ‘compensation’, ‘risks or discomforts’, ‘procedures’, ‘confidentiality’ and ‘benefits’ were under-informed. Participants over 50 years of age, those without a college education and those whose participation was less voluntary were relatively less informed about the clinical trials. Conclusions An information discrepancy was observed between the participants' understanding and their desire to know. By putting more emphasis on under-informed elements, the quality of informed consent could be improved. (shrink)

The causal nature of evolution is one of the central topics in the philosophy of biology. The issue concerns whether equations used in evolutionary genetics point to some causal processes or purely phenomenological patterns. To address this question the present article builds well-defined causal models that underlie standard equations in evolutionary genetics. These models are based on minimal and biologically plausible hypotheses about selection and reproduction, and generate statistics to predict evolutionary changes. The causal reconstruction of the evolutionary principles shows (...) adaptive evolution as a genuine causal process, where fitness and selection are both causes of evolution. 1 Introduction2 The Philosophical Puzzle3 Causal Models4 Causal Foundations of Evolutionary Genetics4.1 Univariate quantitative genetics model4.1.1 The causal graph4.1.2 Structural equations4.1.3 Deriving evolutionary transition functions4.2 One-locus population genetics model5 Evolution as a Causal Process5.1 Selection as a causal process5.2 Causes of evolutionary change6 Conclusion. (shrink)